Vascularization

My MEng and PhD theses were about the design of vascular networks for tissue engineering, and I still provide support to experimental groups regarding this, as well as exploring applications in imaging and industrial reactions.

Contributions

• ‘Procedural generation of vascular networks for tissue engineering’ (PhD thesis, DOI: 10.17863/CAM.99690, embargoed until Jul. 2024).
• Vascular.Networks: a collection of libraries for laying out biomimetic channel networks within arbitrary domains, optimizing them for various costs, and ensuring that they are fluidically distinct and manufacturable.
  • Source
  • Package

Collaborations

I have a few ongoing theoretical and practical collaborations, mostly aimed at identifying issues and areas of improvement for the Vascular.Networks project. If you have an interesting novel manufacturing technique or application for my software, get in touch with me about establishing a collaboration. Otherwise, I am available to hire on a consulting basis for commercial projects.

• Cambridge University Engineering Department — multicasting cell-laden gels around 3D printed templates to create constructs with perfusable channels.
• Centre for Computational Medicine, University College London — generating ground-truth training data from scratch and adding vessels to scan data. (Formerly with the Centre for Advanced Biomedical Imaging.)
• 3B’s Institute, University of Minho — laser ablation and seeding cells on channel walls in hydrogel.

Publications

1. A. A. Guy, A. W. Justin, D. M. Aguilar-Garza, and A. E. Markaki, ‘3D Printable Vascular Networks Generated by Accelerated Constrained Constructive Optimization for Tissue Engineering’, IEEE Transactions on Biomedical Engineering, vol. 67, no. 6, pp. 1650–1663, Jun. 2020, DOI: 10.1109/TBME.2019.2942313